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Breakdowns > Human Immune System > Regulatory & Coordination Layers > Signal Mediators & Set-Points

Function: Tune the gain (cytokines, checkpoints, co-stimulation, system “tone”) and decide when to stop.

The Sickness Behavior Loop (The Neuro-Immune Interface)

22nd January 2026• Category: Breakdowns

Rest is defense....

Specialized Pro-Resolving Mediators

2nd January 2026• Category: Breakdowns

(Resolvins, Protectins, Maresins)...

Type I Interferon Axis (Antiviral Broadcast)

30th September 2025• Category: Breakdowns

The viral alarm system...

IL-1β, IL-6, and TNF (Pro-Inflammatory Triad)

30th September 2025• Category: Breakdowns

Ignite and escalate...

IL-2 Competence Window

30th June 2025• Category: Breakdowns

Calibrating danger...

IL-10 Signaling System

26th June 2025• Category: Breakdowns

The taming whisper...

IL-2 feedback system

23rd June 2025• Category: Breakdowns

Spiral of care...

Immune Tone (Set-Point Calibration Layer)

12th June 2025• Category: Breakdowns

Immune system's balancing act...

Checkpoint Inhibition (PD-1 / CTLA-4)

9th June 2025• Category: Breakdowns

Personalized braking systems...

TGF-β (Transforming Growth Factor Beta)

6th June 2025• Category: Breakdowns

The architect of restraint...

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